The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome | Zendy

Mu Chen | Zendy; Yudong Fei | Zendy; Tai-Zhong Chen | Zendy; YiGang Li | Zendy; PengSheng Chen | Zendy

Open Access

The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome

Author(s) -

Mu Chen,

Yudong Fei,

Tai-Zhong Chen,

YiGang Li,

PengSheng Chen

Publication year - 2021

Publication title -

pflügers archiv - european journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.428

H-Index - 129

eISSN - 0365-267X

pISSN - 0031-6768

DOI - 10.1007/s00424-020-02500-3

Subject(s) - medicine , potassium channel , atrial fibrillation , endocrinology , sexual dimorphism , intracellular , repolarization , apamin , neuroscience , electrical conduction system of the heart , cardiology , biology , electrophysiology , microbiology and biotechnology , electrocardiography

Apamin-sensitive small-conductance calcium-activated potassium (SK) current (I KAS ) plays an important role in cardiac repolarization under a variety of physiological and pathological conditions. The regulation of cardiac I KAS relies on SK channel expression, intracellular Ca 2+ , and interaction between SK channel and intracellular Ca 2+ . I KAS activation participates in multiple types of arrhythmias, including atrial fibrillation, ventricular tachyarrhythmias, and automaticity and conduction abnormality. Recently, sex dimorphisms in autonomic control have been noticed in I KAS activation, resulting in sex-differentiated action potential morphology and arrhythmogenesis. This review provides an update on the Ca 2+ -dependent regulation of cardiac I KAS and the role of I KAS on arrhythmias, with a special focus on sex differences in I KAS activation. We propose that sex dimorphism in autonomic control of I KAS may play a role in J wave syndrome.

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