Open AccessSerotonin 1A agonist and cardiopulmonary improvements with whole-body exercise in acute, high-level spinal cord injury: a retrospective analysis
Author(s) -
Isabelle Vivodtzev,
Glen Picard,
Kevin O’Connor,
J. Andrew Taylor
Publication year - 2020
Publication title -
european journal of applied physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 133
eISSN - 1439-6327
pISSN - 1439-6319
DOI - 10.1007/s00421-020-04536-w
Subject(s) - buspirone , medicine , spinal cord injury , cardiorespiratory fitness , anesthesia , respiratory minute volume , respiratory system , cardiology , ventilation (architecture) , vo2 max , physical therapy , agonist , heart rate , spinal cord , blood pressure , receptor , mechanical engineering , engineering , psychiatry
High-level spinal cord injury (SCI) can result in spinal and supraspinal respiratory control deficits leading to insufficient ventilatory responses to exercise and training-related adaptations. We hypothesized a serotonin agonist, known to improve respiratory function in animal models, would improve adaptations to whole-body functional electrical stimulation (FES) exercise training in patients with acute high-level SCI.