Open AccessProtective effect of the extremolytes ectoine and hydroxyectoine in a porcine organ culture
Author(s) -
Teresa Tsai,
Ana M. MuellerBuehl,
Yathavan Satgunarajah,
Sandra Kuehn,
H. Burkhard Dick,
Stephanie C. Joachim
Publication year - 2020
Publication title -
graefe's archive for clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.196
H-Index - 101
eISSN - 1435-702X
pISSN - 0721-832X
DOI - 10.1007/s00417-020-04854-x
Subject(s) - ectoine , retina , organ culture , hypoxia (environmental) , neuroprotection , apoptosis , biology , pharmacology , pathology , medicine , chemistry , in vitro , biochemistry , neuroscience , proline , organic chemistry , amino acid , oxygen , osmoprotectant
Hypoxic damage to the retina is a relevant component of neurodegenerative pathologies such as glaucoma or retinal ischemia. In porcine retina organ cultures, hypoxic damage can be induced by applying cobalt chloride (CoCl 2 ). The aim of our study was to investigate possible neuroprotective effects of the extremolytes ectoine and hydroxyectoine in this hypoxia-damaged retina model.