Open AccessEffect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial
Author(s) -
James L. Dorling,
Éric Ravussin,
Leanne M. Redman,
Manju Bhapkar,
Kim M. Huffman,
Susan B. Racette,
Sai Krupa Das,
John W. Apolzan,
William E. Kraus,
Christoph Höchsmann,
Corby K. Martin
Publication year - 2020
Publication title -
european journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.321
H-Index - 96
eISSN - 1436-6215
pISSN - 1436-6207
DOI - 10.1007/s00394-020-02361-7
Subject(s) - medicine , obesity , alkaline phosphatase , calorie restriction , randomized controlled trial , body mass index , bilirubin , calorie , gastroenterology , liver disease , endocrinology , gamma glutamyltransferase , chemistry , biochemistry , enzyme
Calorie restriction (CR) is an effective treatment for obesity-related liver and metabolic disease. However, CR studies in individuals without obesity are needed to see if CR could delay disease onset. Liver biomarkers indicate hepatic health and are linked to cardiometabolic disease. Our aim was to examine the effects of a 2-year CR intervention on liver biomarkers in healthy individuals without obesity.