Open AccessHigh-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice
Author(s) -
Aaron Magnuson,
Daniel P. Regan,
Andrea Booth,
Josephine K. Fouts,
Claudia M. Solt,
Jessica L. Hill,
Steve W. Dow,
Michelle T. Foster
Publication year - 2019
Publication title -
european journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.321
H-Index - 96
eISSN - 1436-6215
pISSN - 1436-6207
DOI - 10.1007/s00394-019-02019-z
Subject(s) - adipose tissue , lymph , lymph node , immune system , fibrosis , inflammation , lymphatic system , medicine , endocrinology , lymph node stromal cell , immunology , pathology
Accumulation of visceral, but not subcutaneous, adipose tissue is highly associated with metabolic disease. Inflammation inciting from adipose tissue is commonly associated with metabolic disease risk and comorbidities. However, constituents of the immune system, lymph nodes, embedded within these adipose depots remain under-investigated. We hypothesize that, lymph nodes are inherently distinct and differentially respond to diet-induced obesity much like the adipose depots they reside in.