Open AccessHigh-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration
Author(s) -
Jennifer N. Walker,
Ana L. Flores-Mireles,
Aaron J L Lynch,
Jerome S. Pinkner,
Michael G. Caparon,
Scott J. Hultgren,
Alana Desai
Publication year - 2019
Publication title -
world journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 83
eISSN - 1433-8726
pISSN - 0724-4983
DOI - 10.1007/s00345-019-03027-8
Subject(s) - medicine , antibiotics , bacteriuria , urinary system , catheter , biofilm , enterococcus faecalis , staphylococcus epidermidis , urine , urinalysis , intensive care medicine , microbiology and biotechnology , surgery , bacteria , staphylococcus aureus , biology , genetics
Catheter-associated urinary tract infections (CAUTIs) are a significant cause of morbidity worldwide, as they account for 40% of all hospital-associated infections. Microbial biofilm formation on urinary catheters (UCs) limits antibiotic efficacy, making CAUTI extremely difficult to treat. To gain insight into the spatiotemporal microbe interactions on the catheter surface we sought to determine how the presence or absence of bacteriuria prior to catheterization affects the organism that ultimately forms a biofilm on the UC and how long after catheterization they emerge.