Open AccessForever young: the key to rejuvenation during gametogenesis
Author(s) -
Bailey A Koch-Bojalad,
Lauren Carson,
Hong-Guo Yu
Publication year - 2020
Publication title -
current genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 81
eISSN - 1432-0983
pISSN - 0172-8083
DOI - 10.1007/s00294-020-01133-4
Subject(s) - biology , microbiology and biotechnology , gametogenesis , biogenesis , cell division , escrt , gamete , chromatin , genetics , cell , endosome , dna , intracellular , embryo , cryopreservation , gene , sperm
Cell aging is the result of deteriorating competence in maintaining cellular homeostasis and quality control. Certain cell types are able to rejuvenate through asymmetric cell division by excluding aging factors, including damaged cellular compartments and extrachromosomal rDNA circles, from entering the daughter cell. Recent findings from the budding yeast S. cerevisiae have shown that gametogenesis represents another type of cellular rejuvenation. Gametes, whether produced by an old or a young mother cell, are granted a renewed replicative lifespan through the formation of a fifth nuclear compartment that sequesters the harmful senescence factors accumulated by the mother. Here, we describe the importance and mechanism of cellular remodeling at the nuclear envelope mediated by ESCRT-III and the LEM-domain proteins, with a focus on nuclear pore biogenesis and chromatin interaction during gamete rejuvenation.