
Transcriptional regulation of the caspofungin-induced cell wall damage response in Candida albicans
Author(s) -
Marienela Y. Heredia,
Deepika Gunasekaran,
Mélanie Ikeh,
Clarissa J. Nobile,
Jason M. Rauceo
Publication year - 2020
Publication title -
current genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 81
eISSN - 1432-0983
pISSN - 0172-8083
DOI - 10.1007/s00294-020-01105-8
Subject(s) - caspofungin , echinocandin , candida albicans , biology , antifungal drug , corpus albicans , crosstalk , signal transduction , microbiology and biotechnology , fungal pathogen , pathogen , antifungal , amphotericin b , physics , fluconazole , optics
The human fungal pathogen Candida albicans maintains pathogenic and commensal states primarily through cell wall functions. The echinocandin antifungal drug caspofungin inhibits cell wall synthesis and is widely used in treating disseminated candidiasis. Signaling pathways are critical in coordinating the adaptive response to cell wall damage (CWD). C. albicans executes a robust transcriptional program following caspofungin-induced CWD. A comprehensive analysis of signaling pathways at the transcriptional level facilitates the identification of prospective genes for functional characterization and propels the development of novel antifungal interventions. This review article focuses on the molecular functions and signaling crosstalk of the C. albicans transcription factors Sko1, Rlm1, and Cas5 in caspofungin-induced CWD signaling.