Open Accessγδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity
Author(s) -
Cattien V. Nguyen,
Emanual Maverakis,
Matthias Eberl,
Iannis E. Adamopoulos
Publication year - 2019
Publication title -
seminars in immunopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.778
H-Index - 94
eISSN - 1863-2300
pISSN - 1863-2297
DOI - 10.1007/s00281-019-00752-5
Subject(s) - autoimmunity , immune system , immunology , acquired immune system , inflammation , innate immune system , t cell , biology , immunity , t cell receptor
The innate and adaptive arms of the immune system tightly regulate immune responses in order to maintain homeostasis and host defense. The interaction between those two systems is critical in the activation and suppression of immune responses which if unchecked may lead to chronic inflammation and autoimmunity. γδ T cells are non-conventional lymphocytes, which express T cell receptor (TCR) γδ chains on their surface and straddle between innate and adaptive immunity. Recent advances in of γδ T cell biology have allowed us to expand our understanding of γδ T cell in the dysregulation of immune responses and the development of autoimmune diseases. In this review, we summarize current knowledge on γδ T cells and their roles in skin and joint inflammation as commonly observed in rheumatic diseases.