Open AccessEvaluation of the impact of renal impairment on the pharmacokinetics of glasdegib in otherwise healthy volunteers
Author(s) -
M. Naveed Shaik,
Robert R. LaBadie,
Brian Hee,
Geoffrey Chan
Publication year - 2021
Publication title -
cancer chemotherapy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.112
H-Index - 111
eISSN - 1432-0843
pISSN - 0344-5704
DOI - 10.1007/s00280-020-04207-9
Subject(s) - medicine , pharmacokinetics , renal function , confidence interval , adverse effect , urology
Glasdegib is being developed for indications in myeloid malignancies. The effect of renal impairment on the pharmacokinetics (PK) of a single, oral, 100-mg glasdegib dose under fasted conditions was assessed.