Protein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents | Zendy

Guangan He | Zendy; Xiaolei Xie | Zendy; Zahid H. Siddik | Zendy

Open Access

Protein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents

Author(s) -

Guangan He,

Xiaolei Xie,

Zahid H. Siddik

Publication year - 2020

Publication title -

cancer chemotherapy and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.112

H-Index - 111

eISSN - 1432-0843

pISSN - 0344-5704

DOI - 10.1007/s00280-020-04085-1

Subject(s) - oxaliplatin , cisplatin , chemistry , cancer research , cytotoxicity , downregulation and upregulation , carboplatin , biochemistry , biology , in vitro , cancer , chemotherapy , genetics , colorectal cancer , gene

Oxaliplatin and satraplatin demonstrate activity against cisplatin-resistant tumor cells. Although the two platinum analogs are structurally-related, oxaliplatin is more active. Therefore, studies focusing on protein expression profiling were undertaken to identify the molecular mechanism for the difference in antitumor activity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research