Open AccessProtein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents
Author(s) -
Guangan He,
Xiaolei Xie,
Zahid H. Siddik
Publication year - 2020
Publication title -
cancer chemotherapy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.112
H-Index - 111
eISSN - 1432-0843
pISSN - 0344-5704
DOI - 10.1007/s00280-020-04085-1
Subject(s) - oxaliplatin , cisplatin , chemistry , cancer research , cytotoxicity , downregulation and upregulation , carboplatin , biochemistry , biology , in vitro , cancer , chemotherapy , genetics , colorectal cancer , gene
Oxaliplatin and satraplatin demonstrate activity against cisplatin-resistant tumor cells. Although the two platinum analogs are structurally-related, oxaliplatin is more active. Therefore, studies focusing on protein expression profiling were undertaken to identify the molecular mechanism for the difference in antitumor activity.