Metabolism and pharmacokinetics characterization of metarrestin in multiple species | Zendy

Elias Carvalho Padilha | Zendy; Pranav Shah | Zendy; Amy Q. Wang | Zendy; Marc Singleton | Zendy; Emma Hughes | Zendy; Dandan Li | Zendy; Kelly A. Rice | Zendy; Kylie M. Konrath | Zendy; Samarjit Patnaik | Zendy; Juan Marugán | Zendy; Udo Rudloff | Zendy; Xin Xu | Zendy

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Metabolism and pharmacokinetics characterization of metarrestin in multiple species

Author(s) -

Elias Carvalho Padilha,

Pranav Shah,

Amy Q. Wang,

Marc Singleton,

Emma Hughes,

Dandan Li,

Kelly A. Rice,

Kylie M. Konrath,

Samarjit Patnaik,

Juan Marugán,

Udo Rudloff,

Xin Xu

Publication year - 2020

Publication title -

cancer chemotherapy and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.112

H-Index - 111

eISSN - 1432-0843

pISSN - 0344-5704

DOI - 10.1007/s00280-020-04042-y

Subject(s) - pharmacokinetics , metabolism , chemistry , pharmacology , medicine , biochemistry

Metarrestin is a first-in-class pyrrolo-pyrimidine-derived small molecule targeting a marker of genome organization associated with metastasis and is currently in preclinical development as an anti-cancer agent. Here, we report the in vitro ADME characteristics and in vivo pharmacokinetic behavior of metarrestin.

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