Open AccessMetabolism and pharmacokinetics characterization of metarrestin in multiple species
Author(s) -
Elias Carvalho Padilha,
Pranav Shah,
Amy Q. Wang,
Marc Singleton,
Emma Hughes,
Dandan Li,
Kelly A. Rice,
Kylie M. Konrath,
Samarjit Patnaik,
Juan Marugán,
Udo Rudloff,
Xin Xu
Publication year - 2020
Publication title -
cancer chemotherapy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.112
H-Index - 111
eISSN - 1432-0843
pISSN - 0344-5704
DOI - 10.1007/s00280-020-04042-y
Subject(s) - pharmacokinetics , pharmacology , in vivo , cyp3a4 , bioavailability , cytochrome p450 , excretion , microsome , chemistry , adme , oral administration , drug metabolism , in vitro , metabolism , biology , biochemistry , drug , microbiology and biotechnology
Metarrestin is a first-in-class pyrrolo-pyrimidine-derived small molecule targeting a marker of genome organization associated with metastasis and is currently in preclinical development as an anti-cancer agent. Here, we report the in vitro ADME characteristics and in vivo pharmacokinetic behavior of metarrestin.