Open AccessLooking for answers: the current status of neoadjuvant treatment in localized soft tissue sarcomas
Author(s) -
Michael J. Nathenson,
Edward A. Sausville
Publication year - 2016
Publication title -
cancer chemotherapy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.112
H-Index - 111
eISSN - 1432-0843
pISSN - 0344-5704
DOI - 10.1007/s00280-016-3055-1
Subject(s) - medicine , ifosfamide , chemotherapy , oncology , neoadjuvant therapy , radiation therapy , soft tissue sarcoma , soft tissue , sarcoma , clinical trial , surgery , cancer , breast cancer , pathology , cisplatin
Sarcomas are a rare and heterogeneous variant of cancer. The standard of care treatment involves surgical resection with radiation in high-risk patients. Despite appropriate treatment approximately 50 % of patients will suffer and die from recurrent disease. The purpose of this article is to review the current evidence concerning the use of neoadjuvant chemotherapy with or without radiation in soft tissue sarcomas.