Open AccessPD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells
Author(s) -
Atish Patel,
Amit K. Tiwari,
Eduardo E. Chufán,
Kamlesh Sodani,
Nagaraju Anreddy,
Satyakam Singh,
Suresh V. Ambudkar,
Ralph A. Stephani,
ZheSheng Chen
Publication year - 2013
Publication title -
cancer chemotherapy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.112
H-Index - 111
eISSN - 1432-0843
pISSN - 0344-5704
DOI - 10.1007/s00280-013-2184-z
Subject(s) - efflux , atp binding cassette transporter , biology , transporter , multiple drug resistance , abcg2 , pharmacology , microbiology and biotechnology , drug resistance , biochemistry , gene
Specific tyrosine kinase inhibitors were recently reported to modulate the activity of ABC transporters, leading to an increase in the intracellular concentration of their substrate drugs. In this study, we determine whether PD173074, a specific fibroblast growth factor receptor (FGFR) inhibitor, could reverse ABC transporter-mediated multidrug resistance.