Open AccessRobotically Assisted Sonic Therapy (RAST) for Noninvasive Hepatic Ablation in a Porcine Model: Mitigation of Body Wall Damage with a Modified Pulse Sequence
Author(s) -
Katherine C. Longo,
Emily A. Knott,
Rao F. Watson,
John F. Swietlik,
Eli Vlaisavljevich,
Amanda R. Smolock,
Zhen Xu,
Clifford S. Cho,
Lu Mao,
Fred T. Lee,
Timothy J. Ziemlewicz
Publication year - 2019
Publication title -
cardiovascular radiology/cardiovascular and interventional radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.767
H-Index - 83
eISSN - 0342-7196
pISSN - 0174-1551
DOI - 10.1007/s00270-019-02215-8
Subject(s) - ablation , ablation zone , medicine , ultrasound , high intensity focused ultrasound , thrombosis , radiology , biomedical engineering , nuclear medicine , surgery
Robotically assisted sonic therapy (RAST) is a nonthermal, noninvasive ablation method based on histotripsy. Prior animal studies have demonstrated the ability to create hepatic ablation zones at the focal point of an ultrasound therapy transducer; however, these treatments resulted in thermal damage to the body wall within the path of ultrasound energy delivery. The purpose of this study was to evaluate the efficacy and safety of a pulse sequence intended to mitigate prefocal body wall injury.