Open AccessDissecting the immune landscape of tumor draining lymph nodes in melanoma with high-plex spatially resolved protein detection
Author(s) -
Georgia M. Beasley,
Aaron D. Therien,
Eda K. Holl,
Rami N. AlRohil,
M. Angélica Selim,
Nellie E. Farrow,
Liuliu Pan,
Paul A. Haynes,
Yan Liang,
Douglas S. Tyler,
Brent A. Hanks,
Smita K. Nair
Publication year - 2020
Publication title -
cancer immunology, immunotherapy/cancer immunology and immunotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.389
H-Index - 115
eISSN - 1432-0851
pISSN - 0340-7004
DOI - 10.1007/s00262-020-02698-2
Subject(s) - melanoma , cd11c , sentinel lymph node , pathology , lymph , biopsy , medicine , cd3 , immune system , cancer research , biology , cd8 , immunology , phenotype , breast cancer , cancer , gene , biochemistry
In melanoma patients, microscopic tumor in the sentinel lymph-node biopsy (SLN) increases the risk of distant metastases, but the transition from tumor in the SLN to metastatic disease remains poorly understood.