Open AccessANTXR1 (TEM8) overexpression in gastric adenocarcinoma makes the protein a potential target of immunotherapy
Author(s) -
Masoud Sotoudeh,
Ramin Shakeri,
Sanford M. Dawsey,
Bahareh Sharififard,
Naser Ahmadbeigi,
Mahmood Naderi
Publication year - 2019
Publication title -
cancer immunology, immunotherapy/cancer immunology and immunotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.389
H-Index - 115
eISSN - 1432-0851
pISSN - 0340-7004
DOI - 10.1007/s00262-019-02392-y
Subject(s) - adenocarcinoma , immunotherapy , immunohistochemistry , cancer , cancer research , medicine , pathology
Despite the promise of immunotherapy for gastric adenocarcinoma, choices for the selection of effective antigenic targets are very limited. Previously published data and our own in-house computational analysis have suggested that ANTXR1 is a potential target, simultaneously expressed in malignant tumor cells and the endothelial cells of the tumors. However, the expression pattern of ANTXR1 protein in clinical samples of gastric adenocarcinoma has not been fully evaluated.