Open AccessCorrelation of HLA-A02* genotype and HLA class I antigen down-regulation with the prognosis of epithelial ovarian cancer
Author(s) -
Emilia Andersson,
Lisa Villabona,
Kjell Bergfeldt,
Joseph W. Carlson,
Soldano Ferrone,
Rolf Kiessling,
Barbara Seliger,
Giuseppe Masucci
Publication year - 2012
Publication title -
cancer immunology, immunotherapy/cancer immunology and immunotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.389
H-Index - 115
eISSN - 1432-0851
pISSN - 0340-7004
DOI - 10.1007/s00262-012-1201-0
Subject(s) - ovarian cancer , genotype , hazard ratio , human leukocyte antigen , cancer , oncology , antigen , biology , medicine , immunology , gene , genetics , confidence interval
In recent years, evidence is accumulating that cancer cells develop strategies to escape immune recognition. HLA class I HC down-regulation is one of the most investigated. In addition, different HLA haplotypes are known to correlate to both risk of acquiring diseases and also prognosis in survival of disease or cancer. We have previously shown that patients with serous adenocarcinoma of the ovary in advanced surgical stage disease have a particularly poor prognosis if they carry the HLA-A02* genotype. We aimed to study the relationship between HLA-A02* genotype in these patients and the subsequent HLA class I HC protein product defects in the tumour tissue.