Open AccessImmunoPET/NIRF/Cerenkov multimodality imaging of ICAM-1 in pancreatic ductal adenocarcinoma
Author(s) -
Miao Li,
Weijun Wei,
Todd E. Barnhart,
Dawei Jiang,
Tianye Cao,
Kevin Fan,
Jonathan W. Engle,
Jianjun Li,
Wei-Yu Chen,
Weibo Cai
Publication year - 2021
Publication title -
european journal of nuclear medicine and molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.313
H-Index - 163
eISSN - 1619-7089
pISSN - 1619-7070
DOI - 10.1007/s00259-021-05216-3
Subject(s) - biodistribution , flow cytometry , positron emission tomography , in vivo , pathology , cancer research , medicine , monoclonal antibody , icam 1 , adenocarcinoma , molecular imaging , nuclear medicine , chemistry , cancer , cell adhesion molecule , antibody , immunology , biology , microbiology and biotechnology
We dual-labeled an intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (mAb) and evaluated its effectiveness for lesion detection and surgical navigation in pancreatic ductal adenocarcinoma (PDAC) via multiple noninvasive imaging approaches, including positron emission tomography (PET), near-infrared fluorescence (NIRF), and Cerenkov luminescence imaging (CLI).