Open AccessFirst-in-human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain
Author(s) -
Min-Jeong Kim,
Jae Hoon Lee,
Fernanda Juarez Anaya,
Jinsoo Hong,
William H. Miller,
Sanjay Telu,
Prachi Singh,
Michelle Cortes,
Katharine Henry,
George Tye,
Michael P. Frankland,
Jose A. Montero Santamaria,
Jeih San Liow,
Sami S. Zoghbi,
Masahiro Fujita,
Victor W. Pike,
Robert B. Innis
Publication year - 2020
Publication title -
european journal of nuclear medicine and molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.313
H-Index - 163
eISSN - 1619-7089
pISSN - 1619-7070
DOI - 10.1007/s00259-020-04855-2
Subject(s) - radioligand , intraclass correlation , human brain , nuclear medicine , correlation , medicine , pathology , reproducibility , chemistry , neuroscience , biology , receptor , mathematics , geometry , chromatography
This study assessed whether the newly developed PET radioligand [ 11 C]PS13, which has shown excellent in vivo selectivity in previous animal studies, could be used to quantify constitutive levels of cyclooxygenase-1 (COX-1) in healthy human brain.