Open AccessWhole-vessel coronary 18F-sodium fluoride PET for assessment of the global coronary microcalcification burden
Author(s) -
Jacek Kwieciński,
Sebastien Cadet,
Marwa Daghem,
Martin Lyngby Lassen,
Damini Dey,
Marc R Dweck,
Daniel S. Berman,
David E. Newby,
Piotr J. Slomka
Publication year - 2020
Publication title -
european journal of nuclear medicine and molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.313
H-Index - 163
eISSN - 1619-7089
pISSN - 1619-7070
DOI - 10.1007/s00259-019-04667-z
Subject(s) - medicine , coronary calcium score , sodium fluoride , hounsfield scale , coronary artery disease , myocardial infarction , nuclear medicine , coronary arteries , microcalcification , cardiology , coronary angiography , pet ct , radiology , positron emission tomography , artery , computed tomography , coronary artery calcium , fluoride , cancer , chemistry , inorganic chemistry , breast cancer , mammography
18 F-sodium fluoride ( 18 F-NaF) has shown promise in assessing disease activity in coronary arteries, but currently used measures of activity - such as maximum target to background ratio (TBRmax) - are defined by single pixel count values. We aimed to develop a novel coronary-specific measure of 18 F-NaF PET reflecting activity throughout the entire coronary vasculature (coronary microcalcification activity [CMA]).