Open Access18F-fluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L
Author(s) -
Chloé C. Féral,
Floriane S. Tissot,
Lionel Tosello,
Nicolas Fakhry,
F. Sébag,
Karel Pacák,
David Taïeb
Publication year - 2016
Publication title -
european journal of nuclear medicine and molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.313
H-Index - 163
eISSN - 1619-7089
pISSN - 1619-7070
DOI - 10.1007/s00259-016-3586-z
Subject(s) - sdhb , pheochromocytoma , paraganglioma , sdhd , immunohistochemistry , medicine , chemistry , cancer research , pathology , gene , mutation , biochemistry , germline mutation
F-FDOPA is a highly sensitive and specific radiopharmaceutical for pheochromocytoma and paraganglioma (PPGL) imaging. However, 18 F-FDOPA might be falsely negative in these tumors, especially those related to mutations in succinate dehydrogenase genes (SDHx). The aim of the present study was to evaluate the relationship between expression of L-DOPA transporters and 18 F-FDOPA PET imaging results in PPGL.