Imaging of HER3-expressing xenografts in mice using a 99mTc(CO)3-HEHEHE-ZHER3:08699 affibody molecule | Zendy

Anna Orlova | Zendy; Magdalena Malm | Zendy; Maria� Rosestedt | Zendy; Zohreh Varasteh | Zendy; Karl Andersson | Zendy; Ram Kumar Selvaraju | Zendy; Mohamed Altai | Zendy; Hadis Honarvar | Zendy; Joanna Strand | Zendy; Stefan Ståhl | Zendy; Vladimir Tolmachev | Zendy; John Löfblom | Zendy

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Imaging of HER3-expressing xenografts in mice using a 99mTc(CO)3-HEHEHE-ZHER3:08699 affibody molecule

Author(s) -

Anna Orlova,

Magdalena Malm,

Maria� Rosestedt,

Zohreh Varasteh,

Karl Andersson,

Ram Kumar Selvaraju,

Mohamed Altai,

Hadis Honarvar,

Joanna Strand,

Stefan Ståhl,

Vladimir Tolmachev,

John Löfblom

Publication year - 2014

Publication title -

european journal of nuclear medicine and molecular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.313

H-Index - 163

eISSN - 1619-7089

pISSN - 1619-7070

DOI - 10.1007/s00259-014-2733-7

Subject(s) - internalization , cancer research , receptor , receptor tyrosine kinase , biodistribution , chemistry , epidermal growth factor receptor , targeted therapy , in vivo , in vitro , cancer , medicine , biology , biochemistry , microbiology and biotechnology

Human epidermal growth factor receptor type 3 (HER3) is a transmembrane receptor tyrosine kinase belonging to the HER (ErbB) receptor family. Membranous expression of HER3 is associated with trastuzumab resistance in breast cancer and the transition to androgen independence in prostate cancer. Imaging of HER3 expression in malignant tumors may provide important diagnostic information that can influence patient management. Affibody molecules with low picomolar affinity to HER3 were recently selected. The aim of this study was to investigate the feasibility of HER3 imaging using radiolabeled Affibody molecules.

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