Rapid blood clearance and lack of long-term renal toxicity of 177Lu-DOTATATE enables shortening of renoprotective amino acid infusion | Zendy

Raghava Kashyap | Zendy; Price Jackson | Zendy; Michael S. Hofman | Zendy; Peter Eu | Zendy; JeanMathieu Beauregard | Zendy; Diana Zannino | Zendy; Rodney J. Hicks | Zendy

Open Access

Rapid blood clearance and lack of long-term renal toxicity of 177Lu-DOTATATE enables shortening of renoprotective amino acid infusion

Author(s) -

Raghava Kashyap,

Price Jackson,

Michael S. Hofman,

Peter Eu,

JeanMathieu Beauregard,

Diana Zannino,

Rodney J. Hicks

Publication year - 2013

Publication title -

european journal of nuclear medicine and molecular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.313

H-Index - 163

eISSN - 1619-7089

pISSN - 1619-7070

DOI - 10.1007/s00259-013-2504-x

Subject(s) - nephrotoxicity , renal function , medicine , urology , clearance , toxicity , kidney , urinary system

The aim of the study was to investigate the feasibility of shortening the recommended 4-h renoprotective amino acid infusion in patients receiving peptide receptor chemoradionuclide therapy (PRCRT) using radiosensitizing 5-fluorouracil. We evaluated the clearance of radiopeptide from the blood, long-term nephrotoxicity in patients undergoing PRCRT with the conventional 4-h amino acid infusion and renal uptake in patients receiving an abbreviated infusion.

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