In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease | Zendy

Masamichi Yokokura | Zendy; Norio Mori | Zendy; Shunsuke Yagi | Zendy; Etsuji Yoshikawa | Zendy; Mitsuru Kikuchi | Zendy; Yujiro Yoshihara | Zendy; Tomoyasu Wakuda | Zendy; Genichi Sugihara | Zendy; Kiyokazu Takebayashi | Zendy; Shiro Suda | Zendy; Yasuhide Iwata | Zendy; Takatoshi Ueki | Zendy; Kenji J. Tsuchiya | Zendy; Katsuaki Suzuki | Zendy; Kazuhiko Nakamura | Zendy; Yasuomi Ouchi | Zendy

Open Access

In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease

Author(s) -

Masamichi Yokokura,

Norio Mori,

Shunsuke Yagi,

Etsuji Yoshikawa,

Mitsuru Kikuchi,

Yujiro Yoshihara,

Tomoyasu Wakuda,

Genichi Sugihara,

Kiyokazu Takebayashi,

Shiro Suda,

Yasuhide Iwata,

Takatoshi Ueki,

Kenji J. Tsuchiya,

Katsuaki Suzuki,

Kazuhiko Nakamura,

Yasuomi Ouchi

Publication year - 2010

Publication title -

european journal of nuclear medicine and molecular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.313

H-Index - 163

eISSN - 1619-7089

pISSN - 1619-7070

DOI - 10.1007/s00259-010-1612-0

Subject(s) - microglia , precuneus , neuroinflammation , posterior cingulate , medicine , pathology , pittsburgh compound b , in vivo , amyloid (mycology) , alzheimer's disease , dementia , neuroscience , cortex (anatomy) , disease , psychology , biology , inflammation , functional magnetic resonance imaging , microbiology and biotechnology

Amyloid β protein (Aβ) is known as a pathological substance in Alzheimer's disease (AD) and is assumed to coexist with a degree of activated microglia in the brain. However, it remains unclear whether these two events occur in parallel with characteristic hypometabolism in AD in vivo. The purpose of the present study was to clarify the in vivo relationship between Aβ accumulation and neuroinflammation in those specific brain regions in early AD.

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