Update 2020: nomenclature and listing of celiac disease–relevant gluten epitopes recognized by CD4+ T cells | Zendy

Ludvig M. Sollid | Zendy; Jason A. TyeDin | Zendy; ShuoWang Qiao | Zendy; Robert P. Anderson | Zendy; Carmen Gianfrani | Zendy; Frits Koning | Zendy

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Update 2020: nomenclature and listing of celiac disease–relevant gluten epitopes recognized by CD4+ T cells

Author(s) -

Ludvig M. Sollid,

Jason A. TyeDin,

ShuoWang Qiao,

Robert P. Anderson,

Carmen Gianfrani,

Frits Koning

Publication year - 2019

Publication title -

immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.003

H-Index - 91

eISSN - 1432-1211

pISSN - 0093-7711

DOI - 10.1007/s00251-019-01141-w

Subject(s) - epitope , human leukocyte antigen , gluten , biology , disease , immunology , antigen , t cell , virology , immune system , medicine , pathology , biochemistry

Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4 + T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.

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