Open AccessChanges in brain functional connectivity and cognition related to white matter lesion burden in hypertensive patients from SPRINT
Author(s) -
Chintan Shah,
Dhivya Srinivasan,
Güray Erus,
J. Eric Schmitt,
Adhish Agarwal,
Monique E. Cho,
Alan J. Lerner,
William E. Haley,
Manjula Kurella Tamura,
Christos Davatzikos,
R. Nick Bryan,
Yong Fan,
Ilya M. Nasrallah
Publication year - 2021
Publication title -
neuroradiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.811
H-Index - 94
eISSN - 1432-1920
pISSN - 0028-3940
DOI - 10.1007/s00234-020-02614-6
Subject(s) - medicine , default mode network , precuneus , hyperintensity , cognition , white matter , cardiology , cohort , resting state fmri , effects of sleep deprivation on cognitive performance , magnetic resonance imaging , physical medicine and rehabilitation , radiology , psychiatry
Hypertension is a risk factor for cognitive impairment; however, the mechanisms leading to cognitive changes remain unclear. In this cross-sectional study, we evaluate the impact of white matter lesion (WML) burden on brain functional connectivity (FC) and cognition in a large cohort of hypertensive patients from the Systolic Blood Pressure Intervention Trial (SPRINT) at baseline.