Open AccessMagnetic resonance spectroscopy markers of axons and astrogliosis in relation to specific features of white matter injury in preterm infants
Author(s) -
Jessica L. Wisnowski,
Vincent J. Schmithorst,
Tena Rosser,
Lisa Paquette,
Marvin D. Nelson,
Robin L. Haynes,
Michael J. Painter,
Stefan Blüml,
Ashok Panigrahy
Publication year - 2014
Publication title -
neuroradiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.811
H-Index - 94
eISSN - 1432-1920
pISSN - 0028-3940
DOI - 10.1007/s00234-014-1380-9
Subject(s) - astrogliosis , medicine , white matter , magnetic resonance imaging , gestational age , hyperintensity , population , neurology , periventricular leukomalacia , pathology , cardiology , pediatrics , physiology , central nervous system , pregnancy , radiology , biology , genetics , environmental health , psychiatry
Punctate white matter lesions (pWMLs) and diffuse excessive high signal intensity (DEHSI) are commonly observed signal abnormalities on MRI scans of high-risk preterm infants near term-equivalent age. To establish whether these features are indicative abnormalities in axonal development or astroglia, we compared pWMLs and DEHSI to markers of axons and astrogliosis, derived from magnetic resonance spectroscopy (MRS).