Open AccessVarious Facets of Pathogenic Lipids in Infectious Diseases: Exploring Virulent Lipid-Host Interactome and Their Druggability
Author(s) -
Ruchika Dadhich,
Shobhna Kapoor
Publication year - 2020
Publication title -
the journal of membrane biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.591
H-Index - 98
eISSN - 1432-1424
pISSN - 0022-2631
DOI - 10.1007/s00232-020-00135-0
Subject(s) - biology , endocytosis , druggability , interactome , host (biology) , membrane lipids , lipidome , microbiology and biotechnology , virulence , context (archaeology) , lipidomics , cell , genetics , bioinformatics , gene , membrane , paleontology
Lipids form an integral, structural, and functional part of all life forms. They play a significant role in various cellular processes such as membrane fusion, fission, endocytosis, protein trafficking, and protein functions. Interestingly, recent studies have revealed their more impactful and critical involvement in infectious diseases, starting with the manipulation of the host membrane to facilitate pathogenic entry. Thereafter, pathogens recruit specific host lipids for the maintenance of favorable intracellular niche to augment their survival and proliferation. In this review, we showcase the lipid-mediated host pathogen interplay in context of life-threatening viral and bacterial diseases including the recent SARS-CoV-2 infection. We evaluate the emergent lipid-centric approaches adopted by these pathogens, while delineating the alterations in the composition and organization of the cell membrane within the host, as well as the pathogen. Lastly, crucial nexus points in their interaction landscape for therapeutic interventions are identified. Lipids act as critical determinants of bacterial and viral pathogenesis by altering the host cell membrane structure and functions.