Open AccessEffectiveness of beta blockers in patients with and without a history of myocardial infarction
Author(s) -
Sanjay Verma,
Edward L. Peterson,
Bin Liu,
Hani N. Sabbah,
L. Keoki Williams,
David E. Lanfear
Publication year - 2020
Publication title -
european journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 108
eISSN - 1432-1041
pISSN - 0031-6970
DOI - 10.1007/s00228-020-02886-0
Subject(s) - medicine , myocardial infarction , hazard ratio , coronary artery disease , retrospective cohort study , proportional hazards model , percutaneous coronary intervention , relative risk , cohort , cardiology , pharmacy , surgery , confidence interval , family medicine
Studies demonstrating mortality benefit of beta blockers (BB) after myocardial infarction (MI) were conducted before the era of percutaneous intervention and widespread use of statins. Recent retrospective studies show inconsistent results regarding which subgroups of coronary artery disease (CAD) patients' benefit. Most studies did not account for medication changes over time. We evaluated the association of time-varying BB exposure with death in CAD patients with or without a history of MI.