Open AccessProton pump inhibitors and risk of liver cancer and mortality in patients with chronic liver disease: a systematic review and meta-analysis
Author(s) -
Hyun Jin Song,
Xinyi Jiang,
Linda Henry,
Mindie H. Nguyen,
Haesuk Park
Publication year - 2020
Publication title -
european journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 108
eISSN - 1432-1041
pISSN - 0031-6970
DOI - 10.1007/s00228-020-02854-8
Subject(s) - medicine , relative risk , meta analysis , liver cancer , cochrane library , cancer , confidence interval , chronic liver disease , hepatocellular carcinoma , observational study , liver disease , epidemiology , gastroenterology , cirrhosis
Epidemiological studies investigating the use of proton pump inhibitors (PPI) on the risk of liver cancer and/or mortality among persons with chronic liver disease (CLD) have reported conflicting results. We conducted a systematic review and meta-analysis to determine the impact of PPI use on liver cancer and/or death among patients with CLD.