The role and utility of measuring red blood cell methotrexate polyglutamate concentrations in inflammatory arthropathies—a systematic review | Zendy

Hamid J. Mohamed | Zendy; Michael J. Sorich | Zendy; S. Kowalski | Zendy; Ross A. McKin | Zendy; Susanna Proudman | Zendy; Leslie G. Cleland | Zendy; Michael D. Wiese | Zendy

Open Access

The role and utility of measuring red blood cell methotrexate polyglutamate concentrations in inflammatory arthropathies—a systematic review

Author(s) -

Hamid J. Mohamed,

Michael J. Sorich,

S. Kowalski,

Ross A. McKin,

Susanna Proudman,

Leslie G. Cleland,

Michael D. Wiese

Publication year - 2015

Publication title -

european journal of clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.845

H-Index - 108

eISSN - 1432-1041

pISSN - 0031-6970

DOI - 10.1007/s00228-015-1819-x

Subject(s) - methotrexate , medicine , rheumatoid arthritis , adverse effect , arthritis , pharmacology , red blood cell , dosing , immunology

Evidence regarding the relationship between red blood cell methotrexate polyglutamate concentration and response to treatment and adverse drug reactions in patients using methotrexate for inflammatory arthropathies is complex and in some respects appears conflicting. Accordingly, we undertook a systematic analysis of available evidence to determine the clinical utility of dosing methotrexate to a target red blood cell methotrexate polyglutamate concentration.

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