Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects | Zendy

Chise Kodaira | Zendy; Mitsushige Sugimoto | Zendy; Masafumi Nishino | Zendy; Mihoko Yamade | Zendy; Naohito Shirai | Zendy; Shinya Uchida | Zendy; Mutsuhiro Ikuma | Zendy; Shizuo Yamada | Zendy; Hiroshi Watanabe | Zendy; Akira Hishida | Zendy; Takahisa Furuta | Zendy

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Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects

Author(s) -

Chise Kodaira,

Mitsushige Sugimoto,

Masafumi Nishino,

Mihoko Yamade,

Naohito Shirai,

Shinya Uchida,

Mutsuhiro Ikuma,

Shizuo Yamada,

Hiroshi Watanabe,

Akira Hishida,

Takahisa Furuta

Publication year - 2009

Publication title -

european journal of clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.845

H-Index - 108

eISSN - 1432-1041

pISSN - 0031-6970

DOI - 10.1007/s00228-009-0625-8

Subject(s) - lansoprazole , cmax , pharmacokinetics , genotype , bioavailability , pharmacology , cyp2c19 , pharmacodynamics , polymorphism (computer science) , chemistry , medicine , omeprazole , gene , biochemistry

The effect of multidrug resistance transporter gene 1 (MDR1) on the bioavailability and kinetics of several substrates has not yet been fully elucidated. We evaluated the influence of MDR1 C3435T polymorphism on the pharmacokinetics and pharmacodynamics of lansoprazole in Japanese subjects.

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