The effects of FK506, a specific calcineurin inhibitor, on methamphetamine-induced behavioral change and its sensitization in rats | Zendy

Toshio Tsukamoto | Zendy; Masaomi Iyo | Zendy; Kunihiko Tani | Zendy; Yoshimoto Sekine | Zendy; Kenji Hashimoto | Zendy; Yutaka Ohashi | Zendy; Katsuaki Suzuki | Zendy; Yasuhide Iwata | Zendy; Norio Mori | Zendy

Open Access

The effects of FK506, a specific calcineurin inhibitor, on methamphetamine-induced behavioral change and its sensitization in rats

Author(s) -

Toshio Tsukamoto,

Masaomi Iyo,

Kunihiko Tani,

Yoshimoto Sekine,

Kenji Hashimoto,

Yutaka Ohashi,

Katsuaki Suzuki,

Yasuhide Iwata,

Norio Mori

Publication year - 2001

Publication title -

psychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.378

H-Index - 196

eISSN - 1432-2072

pISSN - 0033-3158

DOI - 10.1007/s002130100870

Subject(s) - calcineurin , sensitization , methamphetamine , pharmacology , chemistry , behavioral sensitization , psychology , medicine , neuroscience , biochemistry , receptor , transplantation , nucleus accumbens

FK506 inhibits calcineurin activity, resulting in the inhibition of calcium-dependent intracellular processes. Recent studies have suggested that intracellular calcium is likely to be involved in methamphetamine (MAP)-induced locomotor activity and stereotyped behavior, and in the development of sensitization to MAP.

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