Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade | Zendy

Muhammad Ummear Raza | Zendy; Digavalli V. Sivarao | Zendy

Open Access

Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade

Author(s) -

Muhammad Ummear Raza,

Digavalli V. Sivarao

Publication year - 2021

Publication title -

psychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.378

H-Index - 196

eISSN - 1432-2072

pISSN - 0033-3158

DOI - 10.1007/s00213-021-05856-1

Subject(s) - nmda receptor , intraclass correlation , analysis of variance , audiology , psychology , repeated measures design , evoked potential , medicine , neuroscience , developmental psychology , psychometrics , mathematics , receptor , statistics

Schizophrenia patients consistently show deficits in sensory-evoked broadband gamma oscillations and click-evoked entrainment at 40 Hz, called the 40-Hz auditory steady-state response (ASSR). Since such evoked oscillations depend on cortical N-methyl D-aspartic acid (NMDA)-mediated network activity, they can serve as pharmacodynamic biomarkers in the preclinical and clinical development of drug candidates engaging these circuits. However, there are few test-retest reliability data in preclinical species, a prerequisite for within-subject testing paradigms.

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