Open AccessIntracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice
Author(s) -
Kristyn N. Borrelli,
Carly R. Langan,
Kyra R. Dubinsky,
Karen K. Szumlinski,
William A. Carlezon,
Elena H. Chartoff,
Camron D. Bryant
Publication year - 2021
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-021-05829-4
Subject(s) - brain stimulation reward , stimulation , methamphetamine , conditioned place preference , medial forebrain bundle , psychology , dopamine , medicine , endocrinology , neuroscience , nucleus accumbens , dopaminergic
Methamphetamine (MA) addiction is a major public health issue in the USA, with a poorly understood genetic component. We previously identified heterogeneous nuclear ribonucleoprotein H1 (Hnrnph1; H1) as a quantitative trait gene underlying sensitivity to MA-induced behavioral sensitivity. Mice heterozygous for a frameshift deletion in the first coding exon of H1 (H1 +/- ) showed reduced MA phenotypes including oral self-administration, locomotor activity, dopamine release, and dose-dependent differences in MA conditioned place preference. However, the effects of H1 +/- on innate and MA-modulated reward sensitivity are not known.