Open AccessLack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats
Author(s) -
David J. Reiner,
E. Andrew Townsend,
Javier Orihuel,
Sarah V. Applebey,
Sarah M Claypool,
Matthew L. Banks,
Yavin Shaham,
S. Stevens Negus
Publication year - 2021
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-021-05816-9
Subject(s) - opioid , fentanyl , self administration , heroin , nociception , medicine , extinction (optical mineralogy) , anesthesia , context (archaeology) , addiction , pharmacology , psychology , psychiatry , chemistry , drug , paleontology , mineralogy , receptor , biology
Pain-related factors increase the risk for opioid addiction, and pain may function as a negative reinforcer to increase opioid taking and seeking. However, experimental pain-related manipulations generally do not increase opioid self-administration in rodents. This discrepancy may reflect insufficient learning of pain-relief contingencies or confounding effects of pain-related behavioral impairments. Here, we determined if pairing noxious stimuli with opioid self-administration would promote pain-related reinstatement of opioid seeking or increase opioid choice over food.