Open AccessAlprazolam-induced EEG spectral power changes in rhesus monkeys: a translational model for the evaluation of the behavioral effects of benzodiazepines
Author(s) -
L.F. Berro,
John S Overton,
Jaren A. Reeves-Darby,
James K. Rowlett
Publication year - 2021
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-021-05793-z
Subject(s) - alprazolam , electroencephalography , benzodiazepine , psychology , beta rhythm , neuroscience , anesthesia , pharmacology , medicine , receptor , psychiatry , anxiety
Benzodiazepines induce electroencephalography (EEG) changes in rodents and humans that are associated with distinct behavioral effects and have been proposed as quantitative biomarkers for GABA A receptor modulation. Specifically, central EEG beta and occipital EEG delta activity have been associated with anxiolysis and sedation, respectively. The extent to which nonhuman primates show the same dose- and topography-dependent effects remained unknown.