Open AccessSynergistic antihyperalgesic and antinociceptive effects of morphine and methyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (MP-III-024): a positive allosteric modulator at α2GABAA and α3GABAA receptors
Author(s) -
Mohammad Atiqur Rahman,
Thomas M. Keck,
M. Poe,
Dishary Sharmin,
James M. Cook,
Bradford D. Fischer
Publication year - 2021
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-021-05791-1
Subject(s) - diazepine , chemistry , morphine , nociception , analgesic , pharmacology , carboxylate , stereochemistry , biochemistry , medicine , receptor , organic chemistry , ring (chemistry)
Opioid and GABA A receptors are both located in central nociceptive pathways, and compounds that activate these receptors have pain-relieving properties. To date, the interactive effects of concurrent administration of these compounds in preclinical models of pain-like behaviors have not been assessed.