Open AccessTemporal parameters of enhanced opioid reward after initial opioid exposure in rats
Author(s) -
Megan J. Moerke,
S. Stevens Negus
Publication year - 2021
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05725-3
Subject(s) - opioid , morphine , dosing , brain stimulation reward , anesthesia , medicine , stimulation , pharmacology , receptor , nucleus accumbens
Mu opioid receptor agonists are indispensable for the treatment of pain, but clinical use carries the inherent risk of transition from effective treatment to abuse. Abuse potential appears to increase rapidly during periods of initial opioid exposure in humans, and this increase in opioid reward during initial opioid exposure can be modeled in rats using an intracranial self-stimulation (ICSS) procedure.