Open AccessHousing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress
Author(s) -
Michel Engeln,
Megan E. Fox,
Mary Kay Lobo
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05657-y
Subject(s) - social defeat , self administration , psychology , social stress , stressor , sensitization , conditioned place preference , addiction , context (archaeology) , social isolation , behavioral sensitization , drug , physiology , pharmacology , developmental psychology , medicine , psychiatry , neuroscience , dopamine , nucleus accumbens , paleontology , biology
Stress exposure has a lasting impact on motivated behavior and can exacerbate existing vulnerabilities for developing a substance use disorder. Several models have been developed to examine how stressful experiences shape drug reward. These range from locomotor sensitization and conditioned place preference to the propensity for drug self-administration or responding to drug-predictive cues. While self-administration studies are considered to have more translational relevance, most of the studies to date have been conducted in rats. Further, many self-administration studies are conducted in single-housed animals, adding the additional stressor of social isolation.