Open AccessRole of the GABAa and GABAb receptors of the central nucleus of the amygdala in compulsive cocaine-seeking behavior in male rats
Author(s) -
Wenlin Sun,
Matt B Yuill
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05653-2
Subject(s) - muscimol , baclofen , gabaa receptor , gabab receptor , basolateral amygdala , addiction , punishment (psychology) , psychology , self administration , agonist , pharmacology , neuroscience , amygdala , receptor , medicine , developmental psychology
Compulsive cocaine use, defined as the continued use despite the dire consequences, is a hallmark of cocaine addiction. Thus, understanding the brain mechanism regulating the compulsive cocaine-seeking and cocaine-taking behaviors is essential to understand cocaine addiction and the key to identification of the molecular targets for the development of medications against this condition.