Open AccessMK801-induced locomotor activity in preweanling and adolescent male and female rats: role of the dopamine and serotonin systems
Author(s) -
Sanders A. McDougall,
Matthew G. Apodaca,
Ginny I. Park,
Angie Teran,
T Baum,
Nazaret R. Montejano
Publication year - 2020
Publication title -
psychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05547-3
Subject(s) - medicine , endocrinology , serotonin , monoamine neurotransmitter , reserpine , nmda receptor , dopamine , phencyclidine , neurotransmitter , 5 ht receptor , psychology , chemistry , receptor
MK801, like other NMDA receptor open-channel blockers (e.g., ketamine and phencyclidine), increases the locomotor activity of rats and mice. Whether this behavioral effect ultimately relies on monoamine neurotransmission is of dispute.
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