Open AccessEffects of repeated treatment with monoamine-transporter-inhibitor antidepressants on pain-related depression of intracranial self-stimulation in rats
Author(s) -
LP Legakis,
Ladan Karim-Nejad,
S. Stevens Negus
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05530-y
Subject(s) - pharmacology , reuptake inhibitor , monoamine neurotransmitter , bupropion , serotonin reuptake inhibitor , antidepressant , norepinephrine transporter , stimulation , reuptake , medicine , endocrinology , serotonin , psychology , receptor , pathology , smoking cessation , hippocampus
Synaptic neurotransmission with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) is terminated primarily by reuptake into presynaptic terminals via the DA, NE, and 5-HT transporters (DAT/NET/SERT, respectively). Monoamine transporter inhibitors constitute one class of drugs used to treat both depression and pain, and therapeutic effects by these compounds often require repeated treatment for days or weeks.