Open AccessHDAC6-selective inhibitors decrease nerve-injury and inflammation-associated mechanical hypersensitivity in mice
Author(s) -
Farhana Sakloth,
Lefteris Manouras,
Kleopatra Avrampou,
Vasiliki Mitsi,
Randal A. Serafini,
Kerri D. Pryce,
Valeria Cogliani,
Olivier Berton,
Matthew Jarpe,
Venetia Zachariou
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05525-9
Subject(s) - sni , hdac6 , nerve injury , allodynia , medicine , inflammation , peripheral nerve injury , pharmacology , peripheral , hyperalgesia , nociception , peripheral neuropathy , immunology , histone deacetylase , anesthesia , chemistry , endocrinology , sciatic nerve , histone , receptor , biochemistry , diabetes mellitus , hydrolysis , acid hydrolysis , gene
HDAC6 is a class IIB histone deacetylase expressed at many levels of the nociceptive pathway. This study tested the ability of novel and selective HDAC6 inhibitors to alleviate sensory hypersensitivity behaviors in mouse models of peripheral nerve injury and peripheral inflammation.