Open AccessChronic corticosterone shifts effort-related choice behavior in male mice
Author(s) -
Andrew Dieterich,
Karina Stech,
Prachi Srivastava,
Jay Lee,
Aitesam Sharif,
Benjamin Adam Samuels
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05521-z
Subject(s) - corticosterone , psychology , chronic stress , dopaminergic , psychopharmacology , medicine , developmental psychology , endocrinology , neuroscience , dopamine , psychiatry , hormone
Effort-related choice tasks are used to study aspects of motivation in both rodents and humans (Der-Avakian and Pizzagalli Biol Psychiatry 83(11):932-939, 2018). Various dopaminergic manipulations and antidepressant treatments can shift responding to these tasks (Randall et al. Int J Neuropsychopharmacol 18(2), 2014; Yohn et al. Psychopharmacology 232(7):1313-1323, 2015). However, while chronic stress can precipitate mood disorders in humans, there is relatively little known about whether chronic stress elicits maladaptive behaviors in rodent effort-related choice tasks.