Open AccessQuantification of observable behaviors induced by typical and atypical kappa-opioid receptor agonists in male rhesus monkeys
Author(s) -
Sally L. Huskinson,
Donna M. Platt,
Morgan Brasfield,
Meagan E. Follett,
Thomas E. Prisinzano,
Bruce E. Blough,
Kevin B. Freeman
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05519-7
Subject(s) - agonist , κ opioid receptor , pharmacology , chemistry , opioid , partial agonist , inverse agonist , oxycodone , receptor , medicine , biochemistry
Kappa-opioid receptor (KOR) agonists are antinociceptive but have side effects that limit their therapeutic utility. New KOR agonists have been developed that are fully efficacious at the KOR but may produce fewer or reduced side effects that are typical of KOR agonists.