Open AccessCeftriaxone and mGlu2/3 interactions in the nucleus accumbens core affect the reinstatement of cocaine-seeking in male and female rats
Author(s) -
Carly N. Logan,
Allison R. Bechard,
Peter U. Hámor,
Lizhen Wu,
Marek Schwendt,
Lori A. Knackstedt
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05514-y
Subject(s) - ceftriaxone , nucleus accumbens , pharmacology , medicine , psychology , receptor , chemistry , antibiotics , biochemistry
The beta-lactam antibiotic ceftriaxone reliably attenuates the reinstatement of cocaine seeking. While the restoration of nucleus accumbens core (NA core) GLT-1 expression is necessary for ceftriaxone to attenuate reinstatement, AAV-mediated GLT-1 overexpression is not sufficient to attenuate reinstatement and does not prevent glutamate efflux during reinstatement.