Open AccessNeurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms
Author(s) -
Catherine A. Schweppe,
Caitlin Burzynski,
Subramaniam Jayanthi,
Bruce Ladenheim,
Jean Lud Cadet,
Eliot L. Gardner,
ZhengXiong Xi,
Henriette van Praag,
Amy Hauck Newman,
Thomas M. Keck
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05513-z
Subject(s) - meth , neurochemical , methamphetamine , psychology , self administration , cognition , monoaminergic , dopamine , hippocampus , neuroscience , psychiatry , pharmacology , medicine , serotonin , chemistry , receptor , monomer , organic chemistry , acrylate , polymer
Abuse of the psychostimulant methamphetamine (METH) can cause long-lasting damage to brain monoaminergic systems and is associated with profound mental health problems for users, including lasting cognitive impairments. Animal models of METH exposure have been useful in dissecting the molecular effects of the drug on cognition, but many studies use acute, non-contingent "binge" administrations of METH which do not adequately approximate human METH use. Long-term METH exposure via long-access (LgA) self-administration paradigms has been proposed to more closely reflect human use and induce cognitive impairments.