Open AccessStress-induced impairment in fear discrimination is causally related to increased kynurenic acid formation in the prefrontal cortex
Author(s) -
Alex Klausing,
Tsutomu Fukuwatari,
David J. Bucci,
Robert Schwarcz
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05507-x
Subject(s) - kynurenic acid , prefrontal cortex , kynurenine , psychology , microdialysis , neuroscience , stressor , corticosterone , kynurenine pathway , cognition , medicine , glutamate receptor , dopamine , chemistry , tryptophan , receptor , amino acid , hormone , biochemistry
Stress is related to cognitive impairments which are observed in most major brain diseases. Prior studies showed that the brain concentration of the tryptophan metabolite kynurenic acid (KYNA) is modulated by stress, and that changes in cerebral KYNA levels impact cognition. However, the link between these phenomena has not been tested directly so far.